发表论文

2019  Publications

1. Yunfeng Gao, Hui Zhang, Nannan Zhou, Pingwei Xu, Jianxiong Wang, Yuan Gao, Xun Jin, Xiaoyu Liang, Jiadi Lv, Yamin Zhang, Ke Tang, Jingwei Ma, Huafeng Zhang, Jing Xie, Fang Yao, Weimin Tong, Yu-Ying Liu*, Ximo Wang*Huang B*. Mobilization of neutrophils by MTX-packaging tumor microparticles confers treatment efficacy for obstructive cholangiocarcinoma. Nature Biomedical Engineering. 2019 (accepted). (IF=17.135)

2. Qingle Liang, Nana Bie, Tuying Yong, Ke Tang, Xiaolong Shi, Zhaohan Wei, Haibo Jia, Xiaoqiong Zhang, Haiyan Zhao, Wei Huang, Lu Gan*, Bo Huang*, Xiangliang Yang*. The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency. Nature Biomedical Engineering. 2019 Sep;3(9):729-740. (IF=17.135)

3. Ke Tang, Yuandong Yu, Liyan Zhu, Pingwei Xu, Jie Chen, Jingwei Ma, Huafeng Zhang, Haiqing Fang, Weiwei Sun, Li Zhou, Keke Wei, Fei Li, Jiadi Lv, Jing Xie, Yuying Liu, Bo Huang*. Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells. Oncogene. 2019 Aug 13. (IF=6.634)

4. Liu Y, Zhang T, Zhou Y, Li J, Liang X, Zhou N, Lv J, Xie J, Cheng F, Fang Y, Gao Y, Wang N & Huang B*, Visualization of perforin/gasdermin/complement in real cell membranes using atomic force microscopy. Cell Mol Immunol. 2019 Jun;16(6):611-620.(IF=7.551)


2018  Publications

1. Liu Y, Lv J, Huang B*, Mediating the death of dormant tumor cells. Molecular & Cellular Oncology. 2018;5:e1458013.

2. Zhang H, Yu Y, Zhou L, Ma J, Tang K, Xu P, Ji T, Liang X, Lv J, Dong W, Zhang T, Chen D, Xie Jing, Liu Y, Huang B*. Circulating tumor microparticles promote lung metastasis by reprogramming inflammatory and mechanical niches via a macrophage-dependent pathway. Cancer Immunol Res. 2018;6:1046-56. (IF: 9.188)

3. Ma J, Wei K, Zhang H, Tang K, Li F, Zhang T, Liu J, Xu P, Yu Y, Sun W, Zhu L, Chen J, Zhou L, Liang X, Lv J, Fiskesund R, Liu Y, Huang B*. Mechanisms underlying presentation of tumor microparticle antigens to CD8+ T cells by dendritic cells. Cancer Immunol Res. 2018;6:1057-68. (IF: 9.188)

4. Liu Y, Lv J, Liang X, Yin X, Zhang L, Chen D, Jin X, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Xie J, Wang N, Huang B*. 3D Fibrin Stiffness mediates Dormancy of Tumor-repopulating cells via a Cdc42-driven Tet2 Epigenetic Program. Cancer Res. 2018;78:3926-37. (IF: 9.122)

5. Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Qin FX, Huang B*. Tumor repopulating cells induce PD-1 expression in CD8+ T cells by transferring kynurenine and AhR activation. Cancer Cell. 2018;33:480-494. (IF: 27.407)

6. Liu Y, Lv J, Liu J, Liang X, Jin X, Xie J, Zhang L, Chen D, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Jia Q, Zhu B, Kong Y, Guo J, Zhang H, Hu ZW, Cao X, Qin FX, Huang B*. STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells. J Clin Invest. 2018;128:1057-73. (IF: 12.784)

7. Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, Jin X, Liu J, Mo S, Zhang T, Cheng F, Zhou Y, Zhang H, Tang K, Ma J, Liu Y, Huang B*. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages towards M1 phenotype. Nat Commun. 2018;9:873. (IF: 12.124)

8. Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, Chen D, Liang X, Yin X, Liu Y, Ma J, Tang K, Zhang Y, Peng Y, Lu J, Zhang Y, Qin X, Cao X, Wan Y, Huang B*. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27. (IF: 20.060)

 

2017  Publications

1. Liu J, Ma J, Tang K, Huang B*. Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles. Methods Mol Biol. 2017;1660:433-440.

2. Luo S, Li Y, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Liu N, Zhang Y, Sun Y, Ji T, Liang X, Yin X, Liu Y, Tong W, Niu Y, Wang N, Wang X,Huang B*. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma. Oncogene. 2017 Jun 22;36(25):3609-3617. (IF: 7.519)

3. Sun Y, Zheng Z, Zhang H, Yu Y, Ma J, Tang K, Xu P, Ji T, Liang X, Chen D, Jin X, Zhang T, Long Z, Liu Y, Huang B*. Chemotherapeutic tumor microparticles combining low dose irradiation reprogram tumor-promoting macrophages through a tumor-repopulating cell-curtailing pathway. Oncoimmunology2017 Mar 31;6(6):e1309487. (IF: 7.719)

4. Liu Y, Liang X, Yin X, Lv J, Tang K, Ma J, Ji T, Zhang H, Dong W, Jin J, Chen D, Li Y, Zhang S, Xie H, Zhao B, Zhao T, Lu J, Hu Z, Cao X, Qin X, Huang B*. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells. Nat Commun2017 May 10;8:15207. (IF: 12.124)

5. Dong W, Zhang H, Yin X, Liu Y, Chen D, Liang X, Jin X, Lv J, Ma J, Tang K, Hu Z, Qin X, Huang B*. Oral delivery of tumor microparticle vaccines activates NOD2 signaling pathway in ileac epithelium rendering potent antitumor T cell immunity. OncoImmunology. 2017 Jan 19;6(3):e1282589. (IF: 7.719)

6. Jin X, Ma J, Liang X, Tang K, Liu Y, Yin X, Zhang Y, Zhang H, Xu P, Chen D, Zhang T, Lu J, Hu Z, Qin X, Zeng X, Li L, Huang B*. Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway. Biomaterials. 2017 Jan;113:93-104. (IF=8.402)

7. Li K, Wang F, Cao WB, Lv XX, Hua F, Cui B, Yu JJ, Zhang XW, Shang S, Liu SS, Yu JM, Han MZ, Huang B, Zhang TT, Li X, Jiang JD, Hu ZW. TRIB3 promotes APL progression through stabilization of the oncoprotein PML-RARα and inhibition of p53-mediated senescence. Cancer Cell. 2017 May 8;31(5):697-710. (IF: 27.407)

 

2016  Publications

1. Ma J, Zhang Y, Tang K, Zhang H, Yin X, Li Y, Xu P, Sun Y, Ma R, Ji T, Chen J, Zhang S, Zhang T, Luo S, Jin Y, Luo X, Li C, Gong H, Long Z, Lu J, Hu Z, Cao X, Wang N, Yang X, Huang B*. Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Res2016 Jun;26(6):713-27.(IF=15.606)

2. Ran L, Tan X, Li Y, Zhang H, Ma R, Ji T, Dong W, Tong T, Liu Y, Chen D, Yin X, Liang X, Tang K, Ma J, Zhang Y, Cao X, Hu Z, Qin X,Huang B* . Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy. Biomaterials2016 May;89:56-66. (IF=8.402)

3. Ma R, Ji T, Chen D, Dong W, Zhang H, Yin X, Ma J, Liang X, Zhang Y, Shen G, Qin X, Huang B*. Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression. Oncoimmunology. 2016 Feb 18;5(4):e1118599. (IF=7.719)

4. Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X, Huang B, Xu X, Zheng J, Cao X. Tumor exosomal rnas promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils. Cancer Cell. 2016 Aug 8;30(2):243-256. (IF: 27.407)

 

2015 Publications

1. Tang K, Hu L, Ma J, Zhang H, Zhang Y, Li Y, Ma R, Luo S, Liu D, Long G, Han M, Liu S, Song A, Shen M, Hu G, Huang B*. Brief Report: Human mesenchymal stem-like cells facilitate floating tumorigenic cell growth via glutamine-ammonium cycle. Stem Cells. 2015 Sep;33(9):2877-84. (IF: 5.599)

2. Wang Z, Cheng Q, Tang K, Sun Y, Zhang K, Zhang Y, Luo S, Zhang H, Ye D, Huang B*. Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells. Cancer Lett. 2015 Aug 10;364(2):118-24. (IF: 6.375)

3. Zhang H & Huang B*. Tumor cell-derived microparticles: a new form of cancer vaccine. Oncoimmunology. 2015 May 27;4(8):e1017704.IF=7.719

4. Cao Y, Liu C, Gu Z, Zhang Y, Duan Y, Zhang Y, Zhang H, Tang K, Huang B*. Microparticles mediate human papillomavirus type 6 or 11 infection of human macrophages.Cell Mol Immunol. 2015 Apr 20. (IF: 5.897)

5. Li Y, Luo S, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Zhang Y, Liang X, Sun Y, Ji T, Wang N, Huang B*. Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors. Cancer Res. 2015 Apr 1;75(7):1191-6. (IF: 9.122)

6. Zhang H, Tang K, Zhang Y, Ma R, Ma J, Li Y, Luo S, Liang X, Ji T, Gu Z, Lu J, He W, Cao X, Wan Y, Huang B*. Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling. Cancer Immunol Res. 2015 Feb;3(2):196-205. (IF: 8.284)

7. Hua F, Li K, Yu JJ, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, Hu ZW*. TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/ proteasomal degradations. Nat Commun. 2015, 13;6:7951. (IF: 12.124)

 

2014  Publication

1. Zhao J, Zeng W, Cao Y, Liang X, Huang B*. Immunotherapy of HPV infection-caused genital warts using low dose cyclophosphamide. Expert Rev Clin Immunol. 2014 Jun;10(6):791-9. (IF: 3.27)

 

2013  Publications

1. Ma R, Zhang W, Tang K, Zhang H, Zhang Y, Li D, Li Y, Xu P, Luo S, Cai W, Ji T, Katirai F, Ye D, Huang B*. Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun. 2013;4:2508. (IF:12.124)

2. Li D, Cai W, Gu R, Zhang Y, Zhang H, Tang K, Xu P, Katirai F, Shi W, Wang L, Huang T, Huang B*. Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients. Clin Immunol. 2013 Dec;149(3):411-20. (IF:4.034)

3. Ma J, Cai W, Zhang Y, Huang C, Zhang H, Liu J, Tang K, Xu P, Katirai F, Zhang J, He W, Ye D, Shen GX, Huang B*. Innate immune cell-derived microparticles facilitate hepatocarcinoma metastasis by transferring integrin αMβ2 to tumor cells. J Immunol. 2013 Sep 15;191(6):3453-61. (IF: 4.856)

4. Xu Z, Zhao J, Zhang H, Ke T, Xu P, Cai W, Katirai F, Ye D, Huang Y, Huang B*. Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4 axis. J Immunol. 2013 Jun 15;190(12):6051-8. (IF: 4.856)

 

2012  Publications

1. Liu J, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, Poh YC, Tang K, Wang N, Huang B*. Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater. 2012 Jul 1;11(8):734-41. (IF: 39.737)

2. Tang K, Zhang Y, Zhang H, Xu P, Liu J, Ma J, Lv M, Li D, Katirai F, Shen GX, Zhang G, Feng ZH, Ye D, Huang B*. Delivery of chemotherapeutic drugs in tumour cell-derived microparticles. Nat Commun. 2012;3:1282. (IF: 12.124)

3. Zhang Y, Zhang R, Zhang H, Liu J, Yang Z, Xu P, Cai W, Lu G, Cui M, Schwendener RA, Shi HZ, Xiong H, Huang B*.Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity. Cell Mol Immunol. 2012;9:489-496. (IF: 5.897)

4. Li D, Jia H, Zhang H, Lv M, Liu J, Zhang Y, Huang T, Huang B*.TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b. Oncoimmunology. 2012;1:687-693. (IF: 7.719)

5. Lv M, Zhang X, Jia H, Li D, Zhang B, Zhang H, Hong M, Jiang T, Jiang Q, Lu J, Huang X, Huang B*. An oncogenic role of miR-142-3p in human T cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor alpha and cAMP/PKA pathways. Leukemia. 2012;26:769-777. (IF: 12.104)

 

2011  Publications

1. Liu J, Zhao J, Hu L, Cao Y, Huang B*. Low Dosages: new chemotherapeutic weapons on the battlefield of immune-related diseases.Cell Mol Immunol. 2011;8:289-295. (IF: 5.897)

2. Liu J, Zhang Y, Zhao J, Yang Z, Li D, Katirai F, Huang B*. Mast cell: insight into remodeling a tumor microenvironment. Cancer Metastasis Rev. 2011;30:177-184. (IF: 4.697)

3. Ouyang X, Yang Z, Zhang R, Arnaboldi P, Lu G, Li Q, Wang W, Zhang B, Cui M, Zhang H, Liang-Chen J, Qin L, Zheng F, Huang B*, Xiong H*. Potentiation of Th17 cytokines in aging process contributes to the development of colitis. Cell Immunol. 2011;266:208-217. (IF: 3.172)

 

2010  Publications

1. Zhang B, Jia H, Liu J, Yang Z, Jiang T, Tang K, Li D, Huang C, Ma J, Shen GX, Ye D, Huang B*. Depletion of T regulatory cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4. J Immunol.2010;185:7199-7206. (IF: 4.856)

2. Tang K, Liu J, Yang Z, Zhang B, Zhang H, Huang C, Ma J, Shen GX, Ye D, Huang B*. Microparticles mediate enzyme transfer from platelets to mast cells: A new pathway for lipoxin A4 biosynthesis. Biochem Biophys Res Commun. 2010;400:432-436. (IF: 2.446)

3. Zhao J, Cao Y, Lei Z, Yang Z, Zhang B, Huang B*. Selective Depletion of CD4+CD25+Foxp3+ Regulatory T Cells by Low-Dose Cyclophosphamide Is Explained by Reduced Intracellular ATP Levels. Cancer Res. 2010;70:4850-4858. (IF: 9.122)

4. Cao Y, Zhao J, Yang Z, Cai Z, Zhang B, Zhou Y, Shen GX, Chen X, Li S, Huang B*. CD4+FOXP3+ regulatory T cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomataacuminata after laser therapy. Clin Immunol. 2010;136:21-29. (IF: 4.034)

5. Zhou Y, Wang S, Ma JW, Lei Z, Zhu HF, Lei P, Yang ZS, Zhang B, Yao XX, Shi C, Sun LF, Wu XW, Ning Q, Shen GX, Huang B*. HBx-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. J Biol Chem. 2010;285:12159-12168. (IF: 4.125)

6. Li B, Lei Z, Lichty BD, Li D, Zhang GM, Feng ZH, Wan Y, Huang B*. Autophagy facilitates major histocompatibility complex class I expression induced by IFN-gamma in B16 melanoma cells. Cancer Immunol Immun. 2010;59:313-321. (IF: 4.711)

7. Yang Z, Lei Z, Li B, Zhou Y, Zhang GM, Feng ZH, Zhang B, Shen GX, Huang B*. Rapamycin inhibits lung metastasis of B16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signaling. Cancer Sci. 2010; 101:494-500. (IF: 3.974)

8. Yang Z, Zhang B, Li D, Lv M, Huang C, Shen GX, Huang B*. Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model. PLoS One. 2010 Jan 27;5(1):e8922. (IF: 2.806)

 

2009  Publications

1. Zhao J, Lei Z, Liu Y, Li B, Zhang L, Fang H, Song C, Wang X, Zhang GM, Feng ZH, Huang B*. Human Pregnancy Upregulates Tim-3 in Innate Immune Cells for Systemic Immunity. J Immunol. 2009; 182:6618-6624. (IF: 4.856)

2. Huang B*, Zhao J, Lei Z, Shen S, Li D, Shen GX, Zhang GM, Feng ZH*. miR-142-3p Regulates cAMP Production in T cells by Targeting Adenylyl Cyclase 9 mRNA. EMBO Rep. 2009; 10:180-185. (IF: 8.568)

3. Lei Z, Zhang GM, Hong M, Feng ZH, Huang B*. Fusion of dendritic cells and CD34+CD38- acute myeloid leukemia (AML) cells potentiates targeting AML-initiating cells by specific CTL induction. J Immunother. 2009; 32:408-414. (IF: 3.712)

4. Lei Z, Li B, Yang Z, Fang H, Zhang GM, Feng ZH, Huang B*. Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One. 2009 Oct 29;4(10):e7629. (IF: 2.806)

 

2008  Publications

1. Song C, Luo L, Lei Z, Li B, Liang Z, Liu G, Li D, Zhang G, Huang B*, Feng ZH*. IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. J Immunol. 2008; 181:6117-6124. (IF: 4.856)

2. Huang B*, Lei Z, Zhang GM, Li D, Song C, Li B, Liu Y, Yuan Y, Unkeless J, Xiong H, Feng ZH*.SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood. 2008; 112:1269-1279. (IF: 11.840)

3. Gong W, Zhang GM, Liu Y, Lei Z, Li D, Yuan Y, Huang B*, Feng ZH*. IFN-γ withdrawal after immunotherapy potentiates B16 melanoma invasion and metastasis by intensifying tumor integrin αvβ3 signaling. Int J Cancer. 2008; 123:702-708. (IF: 6.513)

4. Cao Y, Zhao J, Lei Z, Shen S, Liu C, Li D, Liu J, Shen GX, Zhang GM, Feng ZH, Huang B*. Local Accumulation of FOXP3+ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata. J Immunol. 2008; 180:7681-6. (IF: 4.856)

5. Lei Z, Liu G, Huang Q, Lv M, Zu R, Zhang GM, Feng ZH, Huang B*. SCF and IL-31 rather than IL-17 and BAFF are potential indicators in patients with allergic asthma. Allergy. 2008; 63:327-32. (IF: 7.361)

6. Huang B*, Zhao J, Unkeless JC, Feng ZH, Xiong H*. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene. 2008; 27:218-24. (IF:7.519)

 

2007  Publications

1. Xiao H, Huang B(co-first author), Yuan Y, Li D, Han LF, Liu Y, Gong W, Wu FH, Zhang GM, Feng ZH. Soluble PD-1 facilitates 4-1BBL-triggered antitumor immunity against murine H22 hepatocarcinoma in vivo. Clin Cancer Res. 2007; 13:1823-1830. (IF: 9.619)

2. Liu Y, Huang B (co-first author), Yuan Y, Gong W, Xiao H, Li D, Yu ZR, Wu FH, Zhang GM, Feng ZH.Inhibition of hepatocarcinoma and tumor metastasis to liver by gene therapy with recombinant CBD-HepII polypeptide of fibronectin. Int J Cancer. 2007; 121:184-192. (IF: 6.513)

3. Huang B, Zhao J, Shen S, Li H, He KL, Shen GX, Mayer L, Unkeless J, Li D, Yuan Y, Zhang GM, Xiong H, Feng ZH. Listeria monocytogenes promotes tumor growth via tumor cell Toll-like receptor 2 signaling. Cancer Res. 2007; 67:4346-4352. (IF:9.122)

4. Huang B, Lei Z, Zhao J, Gong W, Liu J, Chen Z, Liu Y, Li D, Yuan Y, Zhang GM, Feng ZH. CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers. Cancer Lett. 2007; 252:86-92. (IF: 6.375)

 

2006  Publication

1. Huang B, Pan PY, Li Q, Sato AI, Levy DE, Bromberg J, Divino CM, Chen SH. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor specific T regulatory cell and T cell anergy. Cancer Res. 2006; 66:1123-1131. (IF: 9.122)

 

2005  Publication

1. Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH, Mayer L, Unkeless JC, Xiong H. Toll like receptor(TLR) on tumor cells facilitate evasion of immune surveillance. Cancer Res. 2005; 65:5009-5014. (IF: 9.122)

 


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