2025  Publications

1. Ma J*, Tang L, Xiao J, Tang K, Zhang H, Huang B*. Burning lactic acid: a road to revitalizing antitumor immunity. Front Med. 2025 Mar 22.(IF=3.9)

2. Lu S, Li J, Li Y, Liu S, Liu Y, Liang Y, Zheng X, Chen Y, Deng J, Zhang H, Ma J, Lv J, Wang Y, Huang B*, Tang K*. Succinate-loaded tumor cell-derived microparticles reprogram tumor-associated macrophage metabolism. Sci Transl Med. 2025 Apr 9;17(793):eadr4458.（IF=15.8）

3. Ma K, Xu Y, Cheng H, Tang K, Ma J, Huang B*. T cell-based cancer immunotherapy: opportunities and challenges. Sci Bull (Beijing). 2025 Mar 31:S2095-9273(25)00337-8.（IF=18.8）

4. Ma J, Tong S, Xiao J, Huang B*. Mannose: A game-changer for T cell immunotherapy. Cell Metab. 2025 Feb 4;37(2):313-315.（IF=27.7）

2024  Publications

1. Chen J, Zhou Y, Liu Z, Lu Y, Jiang Y, Cao K, Zhou N, Wang D, Zhang C, Zhou N, Shi K, Zhang L, Zhou L, Wang Z, Zhang H, Tang K, Ma J, Lv J, Huang B*. Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG. Science. 2024 Feb 16;383(6684):eadi3332. (IF=56.9)

2. Ma J, Tang L, Tan Y, Xiao J, Wei K, Zhang X, Ma Y, Tong S, Chen J, Zhou N, Yang L, Lei Z, Li Y, Lv J, Liu J, Zhang H, Tang K, Zhang Y, Huang B*. Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria. Nat Immunol. 2024 Mar;25(3):552-561. (IF=30.5)

3. Zhou Y, Wang D, Zhou L, Zhou N, Wang Z, Chen J, Pang R, Fu H, Huang Q, Dong F, Cheng H, Zhang H, Tang K, Ma J, Lv J, Cheng T, Fiskesund R, Zhang X*, Huang B*. Cell softness renders cytotoxic T lymphocytes and T leukemic cells resistant to perforin-mediated killing. Nat Commun. 2024 Feb 15;15(1):1405. (IF=16.6)

4. Zhang H, Yang Z, Yuan W, Liu J, Luo X, Zhang Q, Li Y, Chen J, Zhou Y, Lv J, Zhou N, Ma J, Tang K, Huang B*. Sustained AhR activity programs memory fate of early effector CD8+ T cells. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2317658121. (IF=11.1)

5. Pan X, Wang J, Zhang L*, Li G*, Huang B*. Metabolic plasticity of T cell fate decision. Chin Med J (Engl). 2024 Apr 5;137(7):762-775. (IF=6.1)

6. Zhang H, Liu J, Yuan W, Zhang Q, Luo X, Li Y, Peng Y, Feng J, Liu X, Chen J, Zhou Y, Lv J, Zhou N, Ma J, Tang K, Huang B*. Ammonia-induced lysosomal and mitochondrial damage causes cell death of effector CD8+ T cells. Nat Cell Biol.  2024 Nov;26(11):1892-1902. (IF=17.3)

2023  Publications

1. Zhou L, Wu D, Zhou Y, Wang D, Fu H, Huang Q, Qin G, Chen J, Lv J, Lai S, Zhang H, Tang K, Ma J, Fiskesund R, Zhang Y, Zhang X*, Huang B*. Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1. Nat Immunol. 2023 Dec;24(12):2042-2052. (IF=30.5)

2. Tang K, Zhang H, Deng J, Wang D, Liu S, Lu S, Cui Q, Chen C, Liu J, Yang Y, Li Y, Chen J, Lv J, Ma J, Huang B*.Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles. Nat Immunol. 2023 Jan;24(1):162-173.(IF=30.5)

3. Wei K, Zhang H, Yang S, Cui Y, Zhang B, Liu J, Tang L, Tan Y, Liu S, Chen S, Yuan W, Luo X, Chen C, Li F, Liu J, Chen J, Xu P, Lv J, Tang K, Zhang Y, Ma J, Huang B*. Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal Transduct Target Ther. 2023 Jan 20;8(1):22.(IF=38.104)

4. Zhou N, Chen J, Ling Z, Zhang C, Zhou Y, Wang D, Zhou L, Wang Z, Sun N, Wang X, Zhang H, Tang K, Ma J, Lv J, Huang B*.Aryl hydrocarbon receptor sulfenylation promotes glycogenolysis and rescues cancer chemoresistance.J Clin Invest. 2023 Dec 15;133(24):e170753. (IF=15.9)

5. Fang Y, Tang Y, Huang B*. Pyroptosis: A road to next-generation cancer immunotherapy. Semin Immunol. 2023 Jul;68:101782.(IF=7.8)

7. Lv J, Zhou Y, Zhou N, Wang Z, Chen J, Chen H, Wang D, Zhou L, Wei K, Zhang H, Tang K, Ma J, Liu Y, Wan Y, Zhang Y, Zhang H, Huang B*. Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells. Sci Transl Med. 2023 Feb;15(681):eabq6024.(IF=19.32)

2022  Publications

1. Zhang H, Liu J, Yang Z, Zeng L, Wei K, Zhu L, Tang L, Wang D, Zhou Y, Lv J, Zhou N, Tang K, Ma J, Huang B. TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells. Mol Cell. 2022 Jun 17:S1097-2765(22)00538-X. (IF=19.328)

2. Lv J, Liu Y, Mo S, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol.2022 Mar;24:364-72. (IF=28.123)

3. Wang Z, Zhou Y, Bao L, Li D, Lv J, Wang D, Li S, Liu J, Qin C*, Tong WM*, Huang B*. Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages. Signal Transduct Target Ther. 2022 Apr 6;7(1):116. (IF=38.104)

4. Wang Z, Lv J, Yu P, Qu Y, Zhou Y, Zhou L, Zhu Q, Li S, Song J, Deng W, Gao R, Liu Y, Liu J, Tong WM, Qin C*, Huang B*. SARS-CoV-2 treatment by ACE2-expressing microparticles is explained by oxidized cholesterol-increased endosomal pH of alveolar macrophages. Cell Mol Immunol.2022 Jan 4;1-12. (IF=22.096)

5. Tang K, Ma J, Huang B. Macrophages' M1 or M2 by tumor microparticles: lysosome makes decision. Cell Mol Immunol. 2022 Oct;19(10):1196-1197. (IF=22.096)

6. Wang Z, Li S, Huang B. Alveolar macrophages: Αchile's heel of SARS-CoV-2 infection. Signal Transduct Target Ther. 2022 Jul 19;7(1):242. (IF=38.104)

7. Chowdhury F, Huang B, Wang N. Forces in stem cells and cancer stem cells. Cells Dev. 2022 Mar 25:203776.

8. Huang B, Cao X. Metabolically targeting immunosuppression and immunoescape for future cancer immunotherapy: a narrative review. Holist Integ Oncol. 1,15 (2022)

2021  Publications

1. Wang Z, Zhou Y, Bao L, Li D, Lv J, Wang D, Li S, Tong WM, Liu J, Qin C*, Huang B*. Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 Delta Variant. Signal Transduct Target Ther.2021 Dec 17;6(1):431. (IF=38.104)

2. Lv J, Yu P, Wang Z, Wang S, Zhou Y, Song J, Tong WM, Liu Y, Qin C*, Huang B*. ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques. Cell Mol Immunol. 2021;18(5):1308-10. (IF=22.096)

3. Lv J, Wang Z, Deng W, Yu P, Song J, Tong WM, Liu J, Liu Y, Qin C*, Huang B*. Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages. Cell Discov. 2021;7(1):24. (IF=38.079)

4. Liu Y, Zhou N, Zhou L, Dong B, Zhao Y, Yuan P, Gao Q, Zhang H, Xiao-Feng Qin F, Huang B. IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor.Nat Immunol. 2021;22(3):358-69. (IF=31.25)

5. Lv J, Liu Y, Cheng F, Li J, Zhou Y, Zhang T, Zhou N,Wang N, Liu Y*, Huang B*. Cell softness regulates tumorigenicity and stemness of cancer cells. EMBO J. 2021;40(2):e106123. (IF=14.012)

6. Liu Y*, Zhang T, Zhang H, Li J, Zhou N, Fiskesund R, Chen J, Lv J, Ma J, Zhang H, Tang K, Zhang X, Wang N, Huang B*. Cell softness prevents cytolytic T cell killing of tumor-repopulating cells. Cancer Res. 2021;81(2):476-88. (IF=13.312)

7. Tang K, Zhu L, Chen J, Wang D, Zeng L, Chen C, Zhou Y, Lv J, Liu Y, Zhang H, Ma J, Huang B. Hypoxia Promotes Breast Cancer Cell Growth by Activating a Glycogen Metabolic Program. Cancer Res. 2021 ;81(19):4949-63. (IF=13.312)

8. Wei Z, Zhang X, Yong T, Bie N, Zhan G, Li X, Liang Q, Li J, Yu J, Zhang B, Gan L*, Huang B*, Yang X*. Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles. Nat Commun. 2021;12(1):440. (IF=17.694)

9. Huang B. Mucins produced by type II pneumocyte: culprits in SARS-CoV-2 pathogenesis. Cell Mol Immunol. 2021;9:1-3. (IF=22.096)

10.  Lv J, Liu Y, Huang B. Mechanical softness: a true stemness feature for cancer cells. Mol Cell Oncol.2021;8(2):1882285.

11. Huang B. Atomic force microscopy: dancing on the stage of immunology. Cell Mol Immunol. 2021;18(6):1605-06. (IF=22.096)

12. Li J, Liu Y, Yuan Y, Huang B. Applications of atomic force microscopy in immunology. Front Med.2021;15(1):43-52. (IF=5.058)

13. Ma J, Tang K, Zhang H, Wei K, Huang B. Characterization and Functional Analysis of Tumor-Derived Microparticles. Curr Protoc. 2021;1(6):e144.

14. Chowdhury F, Huang B, Wang N. Cytoskeletal prestress: The cellular hallmark in mechanobiology and mechanomedicine. Cytoskeleton (Hoboken). 2021; Online ahead of print. (IF=2.844)

2020  Publications

1. Liu Y, Lv J, Liu J, Li M, Xie J, Lv Q, Deng W, Zhou N, Zhou Y, Song J, Wang P, Qin C, Tong WM, Huang B. Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19. Cell Res. 2020 Dec;30(12):1078-1087. (IF=46.297)

2. Xu P, Tang K, Ma J, Zhang H, Wang D, Zhu L, Chen J, Wei K, Liu J, Fang H, Tang L, Zhang Y, Xie J, Liu Y, Meng R, Liu L, Dong X, Yang K, Wu G, Ma F, Huang B. Chemotherapeutic tumor microparticles elicit a neutrophil response targeting malignant pleural effusions. Cancer Immunol Res. 2020 Sep;8(9):1193-1205. (IF=12.020)

3. Gao Y, Zhang H, Zhou N, Xu P, Wang J, Gao Y, Jin X, Liang X, Lv J, Zhang Y, Tang K, Ma J, Zhang H, Xie J, Yao F, Tong W, Liu Y*, Wang X*, Huang B*. Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nat Biomed Eng. 2020 Jul;4(7):743-53. (IF=29.234)

4. Ma J, Wei K, Liu J, Tang K, Zhang H, Zhu L, Chen J, Li F, Xu P, Chen J, Liu J, Fang H, Tang L, Wang D, Zeng L, Sun W, Xie J, Liu Y, Huang B. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Nat Commun. 2020 Apr 14;11(1):1769. (IF=17.694)

5. Zhang H, Tang K, Ma J, Zhou L, Liu J, Zeng L, Zhu L, Xu P, Chen J, Wei K, Liang X, Lv J, Xie J, Liu Y, Wan Y, Huang B. Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T cell memory development. Nat Cell Biol. 2020 Jan;22(1):18-25. (IF=28.123)

6. Liu Y,  Fang Y,  Chen X,  Wang Z,  Liang X,  Lv J,  Tang K,  Xie J,  Gao Y,  Cheng F,  Zhou Y,  Zhang Z,  Hu Y,  Zhang X,  Gao Q,  Zhang Y,  Huang B. Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome. Sci Immunol. 2020 Jan 17;5(43):eaax7969. (IF=30.630)

7. Chen J, Sun W, Zhang H, Ma J, Xu P, Yu Y, Fang H, Zhou L, Lv J, Xie J, Liu Y, Tang K*, Huang B*. Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β. Cell Mol Immunol. 2020;17:1233-1244. (IF=22.096)

8. Zhang H, Ma J, Tang K, Huang B. Beyond energy storage: roles of glycogen metabolism in health and disease. FEBS J. 2020 Nov 29. (IF=5.622)

9. Ma J, Zhang H, Tang K, Huang B. Tumor-derived microparticles in tumor immunology and immunotherapy. Eur J Immunol. 2020 Nov;50(11):1653-1662. (IF=6.688)

2019  Publications

1. Liang Q, Bie N, Yong T, Tang K, Shi X, Wei Z, Jia H, Zhang X, Zhao H, Huang W, Gan L*, Huang B*, Yang X*. The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency. Nat Biomed Eng. 2019 Sep;3(9):729-740. (IF=29.234)

2. Tang K, Yu Y, Zhu L, Xu P, Chen J, Ma J, Zhang H, Fang H, Sun W, Zhou L, Wei K, Li F, Lv J, Xie J, Liu Y, Huang B. Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells. Oncogene. 2019 Oct;38(44):6970-6984. (IF=8.756)

3. Liu Y, Zhang T, Zhou Y, Li J, Liang X, Zhou N, Lv J, Xie J, Cheng F, Fang Y, Gao Y, Wang N , Huang B. Visualization of perforin/gasdermin/complement in real cell membranes using atomic force microscopy. Cell Mol Immunol. 2019 Jun;16(6):611-620. (IF=22.096)

2018  Publications

1. Zhang H, Yu Y, Zhou L, Ma J, Tang K, Xu P, Ji T, Liang X, Lv J, Dong W, Zhang T, Chen D, Xie Jing, Liu Y, Huang B. Circulating tumor microparticles promote lung metastasis by reprogramming inflammatory and mechanical niches via a macrophage-dependent pathway. Cancer Immunol Res. 2018;6:1046-56. (IF=12.020)

2. Ma J, Wei K, Zhang H, Tang K, Li F, Zhang T, Liu J, Xu P, Yu Y, Sun W, Zhu L, Chen J, Zhou L, Liang X, Lv J, Fiskesund R, Liu Y, Huang B. Mechanisms underlying presentation of tumor microparticle antigens to CD8+ T cells by dendritic cells. Cancer Immunol Res. 2018;6:1057-68. (IF=12.020)

3. Liu Y, Lv J, Liang X, Yin X, Zhang L, Chen D, Jin X, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Xie J, Wang N, Huang B. 3D Fibrin Stiffness mediates Dormancy of Tumor-repopulating cells via a Cdc42-driven Tet2 Epigenetic Program. Cancer Res. 2018;78:3926-37. (IF=13.312)

4. Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Qin FX, Huang B. Tumor repopulating cells induce PD-1 expression in CD8+ T cells by transferring kynurenine and AhR activation. Cancer Cell. 2018;33:480-494. (IF=38.585)

5. Liu Y, Lv J, Liu J, Liang X, Jin X, Xie J, Zhang L, Chen D, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Jia Q, Zhu B, Kong Y, Guo J, Zhang H, Hu ZW, Cao X, Qin FX, Huang B. STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells. J Clin Invest. 2018;128:1057-73. (IF=19.456)

6. Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, Jin X, Liu J, Mo S, Zhang T, Cheng F, Zhou Y, Zhang H, Tang K, Ma J, Liu Y, Huang B. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages towards M1 phenotype. Nat Commun. 2018;9:873. (IF=17.694)

7. Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, Chen D, Liang X, Yin X, Liu Y, Ma J, Tang K, Zhang Y, Peng Y, Lu J, Zhang Y, Qin X, Cao X, Wan Y, Huang B. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27. (IF=28.123)

8. Liu Y, Lv J, Huang B. Mediating the death of dormant tumor cells. Mol Cell Oncol. 2018 Aug 6;5(4):e1458013.

2017  Publications

1. Luo S, Li Y, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Liu N, Zhang Y, Sun Y, Ji T, Liang X, Yin X, Liu Y, Tong W, Niu Y, Wang N, Wang X, Huang B. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma. Oncogene. 2017 Jun 22;36(25):3609-3617. (IF=8.756)

2. Sun Y, Zheng Z, Zhang H, Yu Y, Ma J, Tang K, Xu P, Ji T, Liang X, Chen D, Jin X, Zhang T, Long Z, Liu Y, Huang B. Chemotherapeutic tumor microparticles combining low dose irradiation reprogram tumor-promoting macrophages through a tumor-repopulating cell-curtailing pathway. Oncoimmunology. 2017 Mar 31;6(6):e1309487. (IF=7.723)

3. Liu Y, Liang X, Yin X, Lv J, Tang K, Ma J, Ji T, Zhang H, Dong W, Jin J, Chen D, Li Y, Zhang S, Xie H, Zhao B, Zhao T, Lu J, Hu Z, Cao X, Qin X, Huang B. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells. Nat Commun. 2017 May 10;8:15207. (IF=17.694)

4. Dong W, Zhang H, Yin X, Liu Y, Chen D, Liang X, Jin X, Lv J, Ma J, Tang K, Hu Z, Qin X, Huang B. Oral delivery of tumor microparticle vaccines activates NOD2 signaling pathway in ileac epithelium rendering potent antitumor T cell immunity. Oncoimmunology. 2017 Jan 19;6(3):e1282589. (IF=7.723)

5. Jin X, Ma J, Liang X, Tang K, Liu Y, Yin X, Zhang Y, Zhang H, Xu P, Chen D, Zhang T, Lu J, Hu Z, Qin X, Zeng X, Li L, Huang B. Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway. Biomaterials. 2017 Jan;113:93-104. (IF=15.304)

6. Li K, Wang F, Cao WB, Lv XX, Hua F, Cui B, Yu JJ, Zhang XW, Shang S, Liu SS, Yu JM, Han MZ, Huang B, Zhang TT, Li X, Jiang JD, Hu ZW. TRIB3 promotes APL progression through stabilization of the oncoprotein PML-RARα and inhibition of p53-mediated senescence. Cancer Cell. 2017 May 8;31(5):697-710. (IF=38.585)

7. Liu J, Ma J, Tang K, Huang B. Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles. Methods Mol Biol. 2017;1660:433-440.

2016  Publications

1. Ma J, Zhang Y, Tang K, Zhang H, Yin X, Li Y, Xu P, Sun Y, Ma R, Ji T, Chen J, Zhang S, Zhang T, Luo S, Jin Y, Luo X, Li C, Gong H, Long Z, Lu J, Hu Z, Cao X, Wang N, Yang X, Huang B. Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Res. 2016 Jun;26(6):713-27. (IF=46.297)

2. Ran L, Tan X, Li Y, Zhang H, Ma R, Ji T, Dong W, Tong T, Liu Y, Chen D, Yin X, Liang X, Tang K, Ma J, Zhang Y, Cao X, Hu Z, Qin X, Huang B. Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy. Biomaterials. 2016 May;89:56-66. (IF=15.304)

3. Ma R, Ji T, Chen D, Dong W, Zhang H, Yin X, Ma J, Liang X, Zhang Y, Shen G, Qin X, Huang B. Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression. Oncoimmunology. 2016 Feb 18;5(4):e1118599. (IF=7.723)

4. Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X, Huang B, Xu X, Zheng J, Cao X. Tumor exosomal rnas promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils. Cancer Cell. 2016 Aug 8;30(2):243-256. (IF=38.585)

2015  Publications

1. Tang K, Hu L, Ma J, Zhang H, Zhang Y, Li Y, Ma R, Luo S, Liu D, Long G, Han M, Liu S, Song A, Shen M, Hu G, Huang B. Brief Report: Human mesenchymal stem-like cells facilitate floating tumorigenic cell growth via glutamine-ammonium cycle. Stem Cells. 2015 Sep;33(9):2877-84. (IF=5.845)

2. Wang Z, Cheng Q, Tang K, Sun Y, Zhang K, Zhang Y, Luo S, Zhang H, Ye D, Huang B. Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells. Cancer Lett. 2015 Aug 10;364(2):118-24. (IF=9.756)

3. Cao Y, Liu C, Gu Z, Zhang Y, Duan Y, Zhang Y, Zhang H, Tang K, Huang B. Microparticles mediate human papillomavirus type 6 or 11 infection of human macrophages. Cell Mol Immunol. 2015 Apr 20. (IF=22.096)

4. Li Y, Luo S, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Zhang Y, Liang X, Sun Y, Ji T, Wang N, Huang B. Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors. Cancer Res. 2015 Apr 1;75(7):1191-6. (IF=13.312)

5. Zhang H, Tang K, Zhang Y, Ma R, Ma J, Li Y, Luo S, Liang X, Ji T, Gu Z, Lu J, He W, Cao X, Wan Y, Huang B. Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling. Cancer Immunol Res. 2015 Feb;3(2):196-205. (IF=12.020)

6. Hua F, Li K, Yu JJ, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, Hu ZW. TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nat Commun. 2015, 13;6:7951. (IF=17.694)

7. Zhang H, Huang B. Tumor cell-derived microparticles: a new form of cancer vaccine. Oncoimmunology. 2015 May 27;4(8):e1017704. (IF=7.723)

2014  Publications

1. Zhao J, Zeng W, Cao Y, Liang X, Huang B. Immunotherapy of HPV infection-caused genital warts using low dose cyclophosphamide. Expert Rev Clin Immunol. 2014 Jun;10(6):791-9. (IF=5.124)

2013  Publications

1. Ma R, Zhang W, Tang K, Zhang H, Zhang Y, Li D, Li Y, Xu P, Luo S, Cai W, Ji T, Katirai F, Ye D, Huang B. Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun. 2013;4:2508. (IF=17.694)

2. Li D, Cai W, Gu R, Zhang Y, Zhang H, Tang K, Xu P, Katirai F, Shi W, Wang L, Huang T, Huang B. Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients. Clin Immunol. 2013 Dec;149(3):411-20. (IF=10.190)

3. Ma J, Cai W, Zhang Y, Huang C, Zhang H, Liu J, Tang K, Xu P, Katirai F, Zhang J, He W, Ye D, Shen GX, Huang B. Innate immune cell-derived microparticles facilitate hepatocarcinoma metastasis by transferring integrin αMβ2 to tumor cells. J Immunol. 2013 Sep 15;191(6):3453-61. (IF=5.426)

4. Xu Z, Zhao J, Zhang H, Ke T, Xu P, Cai W, Katirai F, Ye D, Huang Y, Huang B. Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4 axis. J Immunol. 2013 Jun 15;190(12):6051-8. (IF=5.426)

2012  Publications

1. Liu J, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, Poh YC, Tang K, Wang N*, Huang B*. Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater. 2012 Jul 1;11(8):734-41. (IF=47.656)

2. Tang K, Zhang Y, Zhang H, Xu P, Liu J, Ma J, Lv M, Li D, Katirai F, Shen GX, Zhang G, Feng ZH, Ye D, Huang B. Delivery of chemotherapeutic drugs in tumour cell-derived microparticles. Nat Commun. 2012;3:1282. (IF=17.694)

3. Zhang Y, Zhang R, Zhang H, Liu J, Yang Z, Xu P, Cai W, Lu G, Cui M, Schwendener RA, Shi HZ, Xiong H, Huang B. Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity. Cell Mol Immunol. 2012;9:489-496.  (IF=22.096)

4. Li D, Jia H, Zhang H, Lv M, Liu J, Zhang Y, Huang T, Huang B. TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b. Oncoimmunology. 2012;1:687-693. (IF=7.723)

5. Lv M, Zhang X, Jia H, Li D, Zhang B, Zhang H, Hong M, Jiang T, Jiang Q, Lu J, Huang X, Huang B. An oncogenic role of miR-142-3p in human T cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor alpha and cAMP/PKA pathways. Leukemia. 2012;26:769-777. (IF=12.883)

2011  Publications

1. Liu J, Zhao J, Hu L, Cao Y, Huang B. Low Dosages: new chemotherapeutic weapons on the battlefield of immune-related diseases. Cell Mol Immunol. 2011;8:289-295. (IF=22.096)

2. Liu J, Zhang Y, Zhao J, Yang Z, Li D, Katirai F, Huang B. Mast cell: insight into remodeling a tumor microenvironment. Cancer Metast Rev. 2011;30:177-184. (IF=9.237)

3. Ouyang X, Yang Z, Zhang R, Arnaboldi P, Lu G, Li Q, Wang W, Zhang B, Cui M, Zhang H, Liang-Chen J, Qin L, Zheng F, Huang B, Xiong H. Potentiation of Th17 cytokines in aging process contributes to the development of colitis. Cell Immunol. 2011;266:208-217. (IF=4.178)

2010  Publications

1. Zhang B, Jia H, Liu J, Yang Z, Jiang T, Tang K, Li D, Huang C, Ma J, Shen GX, Ye D, Huang B. Depletion of T regulatory cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4. J Immunol. 2010;185:7199-7206. (IF=5.426)

2. Tang K, Liu J, Yang Z, Zhang B, Zhang H, Huang C, Ma J, Shen GX, Ye D, Huang B. Microparticles mediate enzyme transfer from platelets to mast cells: A new pathway for lipoxin A4 biosynthesis. Biochem Bioph Res Co. 2010;400:432-436. (IF=3.322)

3. Zhao J, Cao Y, Lei Z, Yang Z, Zhang B, Huang B. Selective Depletion of CD4+CD25+Foxp3+ Regulatory T Cells by Low-Dose Cyclophosphamide Is Explained by Reduced Intracellular ATP Levels. Cancer Res. 2010;70:4850-4858. (IF=13.312)

4. Cao Y, Zhao J, Yang Z, Cai Z, Zhang B, Zhou Y, Shen GX, Chen X, Li S, Huang B. CD4+FOXP3+ regulatory T cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomataacuminata after laser therapy. Clin Immunol. 2010;136:21-29. (IF=10.190)

5. Zhou Y, Wang S, Ma JW, Lei Z, Zhu HF, Lei P, Yang ZS, Zhang B, Yao XX, Shi C, Sun LF, Wu XW, Ning Q, Shen GX, Huang B. HBx-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. J Biol Chem. 2010;285:12159-12168. (IF=5.486)

6. Li B, Lei Z, Lichty BD, Li D, Zhang GM, Feng ZH, Wan Y, Huang B. Autophagy facilitates major histocompatibility complex class I expression induced by IFN-gamma in B16 melanoma cells. Cancer Immunol Immun. 2010;59:313-321. (IF=6.630)

7. Yang Z, Lei Z, Li B, Zhou Y, Zhang GM, Feng ZH, Zhang B, Shen GX, Huang B. Rapamycin inhibits lung metastasis of B16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signaling. Cancer Sci. 2010; 101:494-500. (IF=6.518)

8. Yang Z, Zhang B, Li D, Lv M, Huang C, Shen GX, Huang B. Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model. PLoS One. 2010 Jan 27;5(1):e8922. (IF=3.752)

2009  Publications

1. Zhao J, Lei Z, Liu Y, Li B, Zhang L, Fang H, Song C, Wang X, Zhang GM, Feng ZH, Huang B. Human Pregnancy Upregulates Tim-3 in Innate Immune Cells for Systemic Immunity. J Immunol. 2009; 182:6618-6624. (IF=5.426)

2. Huang B, Zhao J, Lei Z, Shen S, Li D, Shen GX, Zhang GM, Feng ZH. miR-142-3p Regulates cAMP Production in T cells by Targeting Adenylyl Cyclase 9 mRNA. EMBO Rep. 2009; 10:180-185. (IF=9.071)

3. Lei Z, Zhang GM, Hong M, Feng ZH, Huang B. Fusion of dendritic cells and CD34+CD38- acute myeloid leukemia (AML) cells potentiates targeting AML-initiating cells by specific CTL induction. J Immunother. 2009; 32:408-414. (IF=4.912)

4. Lei Z, Li B, Yang Z, Fang H, Zhang GM, Feng ZH, Huang B. Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One. 2009 Oct 29;4(10):e7629. (IF=3.752)

2008  Publications

1. Song C, Luo L, Lei Z, Li B, Liang Z, Liu G, Li D, Zhang G, Huang B, Feng ZH. IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. J Immunol. 2008; 181:6117-6124. (IF=5.426)

2. Huang B, Lei Z, Zhang GM, Li D, Song C, Li B, Liu Y, Yuan Y, Unkeless J, Xiong H, Feng ZH.SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood. 2008; 112:1269-1279. (IF=25.476)

3. Gong W, Zhang GM, Liu Y, Lei Z, Li D, Yuan Y, Huang B, Feng ZH. IFN-γ withdrawal after immunotherapy potentiates B16 melanoma invasion and metastasis by intensifying tumor integrin αvβ3 signaling. Int J Cancer. 2008; 123:702-708. (IF=7.316)

4. Cao Y, Zhao J, Lei Z, Shen S, Liu C, Li D, Liu J, Shen GX, Zhang GM, Feng ZH, Huang B. Local Accumulation of FOXP3+ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata. J Immunol. 2008; 180:7681-6. (IF=5.426)

5. Lei Z, Liu G, Huang Q, Lv M, Zu R, Zhang GM, Feng ZH, Huang B. SCF and IL-31 rather than IL-17 and BAFF are potential indicators in patients with allergic asthma. Allergy. 2008; 63:327-32. (IF=14.71)

6. Huang B, Zhao J, Unkeless JC, Feng ZH, Xiong H. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene. 2008; 27:218-24. (IF=8.756)

2007  Publications

1. Xiao H, Huang B (co-first author), Yuan Y, Li D, Han LF, Liu Y, Gong W, Wu FH, Zhang GM, Feng ZH. Soluble PD-1 facilitates 4-1BBL-triggered antitumor immunity against murine H22 hepatocarcinoma in vivo. Clin Cancer Res. 2007; 13:1823-1830. (IF=13.801)

2. Liu Y, Huang B (co-first author), Yuan Y, Gong W, Xiao H, Li D, Yu ZR, Wu FH, Zhang GM, Feng ZH.Inhibition of hepatocarcinoma and tumor metastasis to liver by gene therapy with recombinant CBD-HepII polypeptide of fibronectin. Int J Cancer. 2007; 121:184-192. (IF=7.316)

3. Huang B, Zhao J, Shen S, Li H, He KL, Shen GX, Mayer L, Unkeless J, Li D, Yuan Y, Zhang GM, Xiong H, Feng ZH. Listeria monocytogenes promotes tumor growth via tumor cell Toll-like receptor 2 signaling. Cancer Res. 2007; 67:4346-4352. (IF=13.312)

4. Huang B, Lei Z, Zhao J, Gong W, Liu J, Chen Z, Liu Y, Li D, Yuan Y, Zhang GM, Feng ZH. CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers. Cancer Lett. 2007; 252:86-92. (IF=9.756)

2006 Publications

1. Huang B, Pan PY, Li Q, Sato AI, Levy DE, Bromberg J, Divino CM, Chen SH. Gr-1⁺CD115⁺ immature myeloid suppressor cells mediate the development of tumor specific T regulatory cell and T cell anergy. Cancer Res. 2006; 66:1123-1131. (IF=13.312)

2005  Publications

1. Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH, Mayer L, Unkeless JC, Xiong H. Toll like receptor(TLR) on tumor cells facilitate evasion of immune surveillance. Cancer Res. 2005; 65:5009-5014. (IF=13.312)