Since its establishment in 2008, the laboratory has been devoted to the research of tumor immunity and tumor biotherapy. In his early years abroad, Prof. Huang, PI of the laboratory, mainly focused on tumor immune escape. The first object of his research was myeloid derived suppressor cells. Prof. Huang found that a large number of myeloid cells were expressed in the bone marrow of tumor mice, and these cells can significantly inhibit the anti-tumor immune response of T cells and promote the progression of tumors, and related work has been published in Cancer research, which has been cited for more than 1200 times. At the same time, it was also originally found that tumor cells express TLRs to mediate tumor immune escape, and related work has also been published in Cancer research and has now been cited more than for 450 times. After returning to China, Prof. Huang established laboratories in the School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology and the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College.
Laboratory research focuses on immunity, oncology, and metabolism, answering the most fundamental questions about cancer, immunity, and metabolism:
Why we get cancer and how we do not get cancer?
If we get cancers how we can do?
What is the work principle of hepatocytes?
How do hepatocytes deal with nutrition and toxins?
Fundamental biology of T cells
The laboratory brings together the core aspects of tumor immunity, tumor metabolism, tumor biomechanical force signal, tumor vesicles and so on, and truly restores the face of tumor, T cells, and metabolism. The main research interests are:
1. Tumor immunity: mechanistic elucidation of fundamental scientific issues related to tumor immunity; Various methods and models have been used to study tumor immunity and the cellular and molecular mechanisms of tumor immune escape. The cellular and molecular components of the tumor microenvironment and the mechanism of anti-tumor therapy; And the cellular and molecular mechanisms of the formation of tumor microenvironment before metastasis;
2. Tumor immunotherapy: microparticles (vesicles) derived from tumor cells are used as carriers to carry chemotherapy drugs and oncolytic viruses to treat tumors; And to study the chemosensitizing effect of microparticles or as a new oral vaccine; Preclinical mechanism of microparticles in the treatment of malignant tumor patients with pleural effusion and ascites; Tumor-specific T cells were isolated from peripheral blood of cancer patients and expanded in vitro;
3. Medical biomechanics: to explore the effect of biomechanics on cell proliferation and differentiation, so as to reveal the mechanism of biomechanical signals in vivo; Using biomechanics to screen cancer stem cells to study the occurrence and development of tumors and to explore new ideas and targets for tumor treatment. To elucidate the physical and mechanical characteristics of stem-like tumor cells;
4. T cell basic biology: T cell memory, thymus atrophy, stem T cell expansion;
5. Metabolism: Answer the core questions such as the nature of glycogen metabolism, why fatty acid oxidation is needed, and the regulation of free radicals.
The laboratory has mature experimental technology, good talent echelon, harmonious research atmosphere, striving research spirit, warmly welcome people with lofty ideals to join our laboratory.
